Cephamycins: Treatment Option for Recurrent Clostridioides difficile Infection

Treatment Strategies for Recurrent Clostridium difficile Infection.

BACKGROUND Recurrent Clostridium difficile infection represents a major clinical challenge. Treatment is often based on empiric selection from relatively few options supported by limited clinical evidence. OBJECTIVE To review and evaluate the literature on therapeutic alternatives for recurrent C. difficile infection. DATA SOURCES The MEDLINE, PubMed, Embase, and Cochrane databases were sea...

Clostridioides difficile Biology: Sporulation, Germination, and Corresponding Therapies for C. difficile Infection

Clostridioides difficile is a Gram-positive, spore-forming, toxin-producing anaerobe, and an important nosocomial pathogen. Due to the strictly anaerobic nature of the vegetative form, spores are the main morphotype of infection and transmission of the disease. Spore formation and their subsequent germination play critical roles in C. difficile infection (CDI) progress. Under suitable condition...

intestinal microbiota transplantation for recurrent clostridium difficile infection

Gut bacterial communities of diarrheic patients with indications of Clostridioides difficile infection

We present bacterial 16S rRNA gene datasets derived from stool samples of 44 patients with diarrhea indicative of a Clostridioides difficile infection. For 20 of these patients, C. difficile infection was confirmed by clinical evidence. Stool samples from patients originating from Germany, Ghana, and Indonesia were taken and subjected to DNA isolation. DNA isolations of stool samples from 35 as...

Fecal microbiota transplantation: a new standard treatment option for Clostridium difficile infection.

The last 20 years have seen a progressive increase in the global incidence and severity of Clostridium difficile infection (CDI), particularly in North America and Europe. This increase has been accompanied by the identification and increased prevalence of new, hypervirulent toxigenic strains such as NAP1/BI/027 [1], which in the USA alone is responsible for worsened outcomes and a mortality re...